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Editorials

Forces in cell biology p579

doi:10.1038/ncb3552

Mechanobiology — the study of how physical forces control the behaviour of cells and tissues — is a rapidly growing field. In this issue, we launch a Series of specially commissioned Review articles that discuss exciting recent developments in this area.


Championing authorship attribution p579

doi:10.1038/ncb3553

Nature Cell Biology is among the Springer Nature journals taking part in a recently launched trial that mandates the provision of ORCID identifiers for the corresponding authors of our papers.


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Review

Multiscale force sensing in development pp581 - 588

Nicoletta I. Petridou, Zoltán Spiró & Carl-Philipp Heisenberg

doi:10.1038/ncb3524

In this Review, we will discuss how the interplay and feedback between mechanical and biochemical signals control tissue morphogenesis and cell fate specification in embryonic development.


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News and Views

Mitochondria link metabolism and epigenetics in haematopoiesis pp589 - 591

John C. Schell & Jared Rutter

doi:10.1038/ncb3540

Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

See also: Article by Liu et al. | Article by Ansó et al.


Cell forces meet cell metabolism pp591 - 593

Tadamoto Isogai, Jin Suk Park & Gaudenz Danuser

doi:10.1038/ncb3542

Epithelial cells form energetically costly cell–cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.

See also: Letter by Bays et al.


Endoglin moves and shapes endothelial cells pp593 - 595

Victoria L. Bautch

doi:10.1038/ncb3543

Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand–receptor signalling and flow-mediated mechanical cues.

See also: Article by Sugden et al. | Article by Jin et al.


Reversing stratification during wound healing pp595 - 597

Denis Headon

doi:10.1038/ncb3545

The involvement of proliferation and migration in epidermal healing has long been recognized, but three studies now reveal how a variety of individual cell behaviours achieve a collective epithelial response, and how diverse repair routes are taken by cells of different origins.

See also: Article by Donati et al. | Article by Park et al. | Article by Aragona et al.


Reducing interferon'ce in stem cells pp597 - 599

Alycia Gardner & Brian Ruffell

doi:10.1038/ncb3544

Little is known regarding how the interactions of stem cells with the immune system regulate their plasticity. A study now describes a mechanism by which normal breast and cancer stem cells utilize miR-199a to downregulate the corepressor LCOR and minimize responses to type I interferon.

See also: Article by Celià-Terrassa et al.


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Articles

Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties pp603 - 613

Giacomo Donati, Emanuel Rognoni, Toru Hiratsuka, Kifayathullah Liakath-Ali, Esther Hoste, Gozde Kar, Melis Kayikci, Roslin Russell, Kai Kretzschmar, Klaas W. Mulder, Sarah A. Teichmann & Fiona M. Watt

doi:10.1038/ncb3532

Donati et al. show that following skin wounding a differentiated Gata6+ cell population resident in the sebaceous duct migrates to the interfollicular epidermis and reattaches to the basal membrane, dedifferentiating into stem cells.

See also: News and Views by Headon


The mitochondrial respiratory chain is essential for haematopoietic stem cell function pp614 - 625

Elena Ansó, Samuel E. Weinberg, Lauren P. Diebold, Benjamin J. Thompson, Sébastien Malinge, Paul T. Schumacker, Xin Liu, Yuannyu Zhang, Zhen Shao, Mya Steadman, Kelly M. Marsh, Jian Xu, John D. Crispino & Navdeep S. Chandel

doi:10.1038/ncb3529

Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

See also: Article by Liu et al. | News and Views by Schell & Rutter


Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation pp626 - 638

Xin Liu, Yuannyu Zhang, Min Ni, Hui Cao, Robert A. J. Signer, Dan Li, Mushan Li, Zhimin Gu, Zeping Hu, Kathryn E. Dickerson, Samuel E. Weinberg, Navdeep S. Chandel, Ralph J. DeBerardinis, Feng Zhou, Zhen Shao & Jian Xu

doi:10.1038/ncb3527

Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

See also: Article by Ansó et al. | News and Views by Schell & Rutter


Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling pp639 - 652

Yi Jin, Lars Muhl, Mikhail Burmakin, Yixin Wang, Anne-Claire Duchez, Christer Betsholtz, Helen M. Arthur & Lars Jakobsson

doi:10.1038/ncb3534

Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.

See also: Article by Sugden et al. | News and Views by Bautch


Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues pp653 - 665

Wade W. Sugden, Robert Meissner, Tinri Aegerter-Wilmsen, Roman Tsaryk, Elvin V. Leonard, Jeroen Bussmann, Mailin J. Hamm, Wiebke Herzog, Yi Jin, Lars Jakobsson, Cornelia Denz & Arndt F. Siekmann

doi:10.1038/ncb3528

Two studies by Sugden et al. and Jin et al. show that endoglin regulates endothelial cell migration through VEGFR2 signalling and controls blood vessel diameter in response to blood flow.

See also: Article by Jin et al. | News and Views by Bautch


Stem cell plasticity enables hair regeneration following Lgr5+ cell loss pp666 - 676

Joerg D. Hoeck, Brian Biehs, Antonina V. Kurtova, Noelyn M. Kljavin, Felipe de Sousa e Melo, Bruno Alicke, Hartmut Koeppen, Zora Modrusan, Robert Piskol & Frederic J. de Sauvage

doi:10.1038/ncb3535

Hoeck et al. show that disruption of the hair follicle stem cell compartment by loss of Lgr5+ stem cells is followed by an inflammatory response and CD34+ stem cell activation and proliferation, to eventually replenish the Lgr5+ population.


Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis pp677 - 688

Matthew Decker, Leticia Martinez-Morentin, Guannan Wang, Yeojin Lee, Qingxue Liu, Juliana Leslie & Lei Ding

doi:10.1038/ncb3530

Decker et al. show that leptin-receptor-positive mesenchymal stromal cells are the source of the fibrogenic myofibroblasts that expand in primary myelofibrosis in a process mediated by PDGFRA pathway activation.


Actin cortex architecture regulates cell surface tension pp689 - 697

Priyamvada Chugh, Andrew G. Clark, Matthew B. Smith, Davide A. D. Cassani, Kai Dierkes, Anan Ragab, Philippe P. Roux, Guillaume Charras, Guillaume Salbreux & Ewa K. Paluch

doi:10.1038/ncb3525

Cortical tension is thought to be generated by myosin II, and little is known about the role of actin network properties. Chugh et al. demonstrate that actin cortex thickness, determined by actin filament length, influences cortical tension.


Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival pp698 - 710

Simon J. Tavernier, Fabiola Osorio, Lana Vandersarren, Jessica Vetters, Nele Vanlangenakker, Gert Van Isterdael, Karl Vergote, Riet De Rycke, Eef Parthoens, Lianne van de Laar, Takao Iwawaki, Juan R. Del Valle, Chih-Chi Andrew Hu, Bart N. Lambrecht & Sophie Janssens

doi:10.1038/ncb3518

Tavernier et al. show that loss of the protective IRE1–XBP1 stress sensor results in the death of conventional dendritic cells in the lung, whereas those in the intestine survive due to a stronger ATF4-dependent stress response and RIDD activation.


Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a–LCOR axis pp711 - 723

Toni Celià-Terrassa, Daniel D. Liu, Abrar Choudhury, Xiang Hang, Yong Wei, Jose Zamalloa, Raymundo Alfaro-Aco, Rumela Chakrabarti, Yi-Zhou Jiang, Bong Ihn Koh, Heath A. Smith, Christina DeCoste, Jun-Jing Li, Zhi-Ming Shao & Yibin Kang

doi:10.1038/ncb3533

Celià-Terrassa et al. find that by repressing LCOR, a modulator of the interferon response, miR-199a allows both normal and cancer mammary stem cells to evade senescence and differentiation, thus promoting tumorigenesis.

See also: News and Views by Gardner & Ruffell


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Letters

Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK pp724 - 731

Jennifer L. Bays, Hannah K. Campbell, Christy Heidema, Michael Sebbagh & Kris A. DeMali

doi:10.1038/ncb3537

Bays et al. demonstrate that application of force to E-cadherin leads to LKB1-dependent activation of AMPK and recruitment of AMPK to E-cadherin complexes to increase glucose uptake and ATP production and re-enforce cell–cell junctions.

See also: News and Views by Isogai et al.


Receptor oligomerization guides pathway choice between proteasomal and autophagic degradation pp732 - 739

Kefeng Lu, Fabian den Brave & Stefan Jentsch

doi:10.1038/ncb3531

Lu et al. show that the choice between proteasomal degradation and selective autophagy is independent of the ubiquitin-binding properties of the receptors but largely determined by oligomerization potential.


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Erratum

Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis p740

Yanhui Zhang, Litao Xie, Susheel K. Gunasekar, Dan Tong, Anil Mishra, William J. Gibson, Chuansong Wang, Trevor Fidler, Brodie Marthaler, Aloysius Klingelhutz, E. Dale Abel, Isaac Samuel, Jessica K. Smith, Lei Cao & Rajan Sah

doi:10.1038/ncb3536


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Corrigendum

Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation p740

Justin Decarreau, Michael Wagenbach, Eric Lynch, Aaron R. Halpern, Joshua C. Vaughan, Justin Kollman & Linda Wordeman

doi:10.1038/ncb3546


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