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Endoglin moves and shapes endothelial cells

Nature Cell Biology volume 19, pages 593–595 (2017)Cite this article

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Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand–receptor signalling and flow-mediated mechanical cues.

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Figure 1: Endothelial cells use endoglin to migrate and remodel vessels.

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Authors and Affiliations

  1. Department of Biology and McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, 27599, North Carolina, USA

    Victoria L. Bautch

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  1. Victoria L. Bautch
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Correspondence to Victoria L. Bautch.

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Bautch, V. Endoglin moves and shapes endothelial cells. Nat Cell Biol 19, 593–595 (2017). https://doi.org/10.1038/ncb3543

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