The role of the epithelial-to-mesenchymal transition in tumour progression remains a topic of intense debate. Now, data on the role of Zeb1 in the metastatic spread of pancreatic cancer clarify apparently conflicting views by revealing context-specific, differential use of individual epithelial-to-mesenchymal transition transcription factors in cancer cell dissemination.
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References
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A. & Thiery, J. P. Cell 166, 21–45 (2016).
Fischer, K. R. et al. Nature 527, 472–476 (2015).
Zheng, X. et al. Nature 527, 525–530 (2015).
Krebs, A. M. et al. Nat. Cell Biol. 19, 518–529 (2017).
Rhim, A. D. et al. Cell 148, 349–361 (2012).
Locascio, A., Manzanares, M., Blanco, M. J. & Nieto, M. A. Proc. Natl Acad. Sci. USA 99, 16841–16846 (2002).
Burk, U. et al. EMBO Rep. 9, 582–589 (2008).
Caramel, J. et al. Cancer Cell 24, 466–480 (2013).
Tran, H. D. et al. Cancer Res. 74, 6330–6340 (2014).
Ye, X. et al. Nature 525, 256–260 (2015).
Trimboli, A. J et al. Cancer Res. 68, 937–945 (2008).
Ocaña, O. H. et al. Cancer Cell 22, 709–724 (2012).
Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S. & Yang, J. Cancer Cell 22, 725–736 (2012).
Beerling, E. et al. Cell Rep. 14, 2281–2288 (2016).
Chaffer, C. L. et al. Cell 154, 61–74 (2013).
Labernadie, A. et al. Nat. Cell Biol. 19, 224–237 (2017).
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Nieto, M. Context-specific roles of EMT programmes in cancer cell dissemination. Nat Cell Biol 19, 416–418 (2017). https://doi.org/10.1038/ncb3520
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DOI: https://doi.org/10.1038/ncb3520
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