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Talin gets SHANKed in the fight for integrin activation

Nature Cell Biology volume 19, pages 265–267 (2017)Cite this article

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Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell–extracellular matrix adhesion, by sequestering integrin activators.

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Figure 1: Shank suppresses talin-mediated integrin activation and adhesion formation.

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Authors and Affiliations

  1. Paul Atherton and Christoph Ballestrem are at the Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK,

    Paul Atherton & Christoph Ballestrem

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  1. Paul Atherton
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  2. Christoph Ballestrem
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Correspondence to Christoph Ballestrem.

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Atherton, P., Ballestrem, C. Talin gets SHANKed in the fight for integrin activation. Nat Cell Biol 19, 265–267 (2017). https://doi.org/10.1038/ncb3501

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