Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.
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Hamey, F., Göttgens, B. Demystifying blood stem cell fates. Nat Cell Biol 19, 261–263 (2017). https://doi.org/10.1038/ncb3494
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DOI: https://doi.org/10.1038/ncb3494
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A robust method for designing multistable systems by embedding bistable subsystems
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