Skeletal muscles are composed of different types of fibres. Can these be thought of as distinct lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential.
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References
Ciciliot, S. & Schiaffino, S. Curr. Pharm. Des. 16, 906–914 (2010).
Mauro, A. J. Biophys. Biochem. Cytol. 9, 493–495 (1961).
Yin, H., Price, F. & Rudnicki, M. A. Physiol. Rev. 93, 23–67 (2013).
Sambasivan, R. et al. Dev. Cell. 16, 810–821 (2009).
DiMario, J. X. Exp. Cell Res. 263, 23–32 (2001).
Liu, N. et al. Nat. Cell Biol. 19, 202–213 (2017).
Wosczyna, M. N., Biswas, A. A., Cogswell, C. A. & Goldhamer, D. J. J. Bone Miner. Res. 27, 1004–1017 (2012).
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A. & Kardon, G. Development 138, 3625–3637 (2011).
Joe, A. W. B. et al. Nat. Cell Biol. 12, 153–163 (2010).
Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S. & Tsuchida, K. Nat. Cell. Biol. 12, 143–152 (2010).
Stark, D. A. et al. J. Cell Biol. 211, 1077–1091 (2015).
Close, R. Nature 206, 831–832 (1965).
von Maltzahn, J., Jones, A. E., Parks, R. J. & Rudnicki, M. A. Proc. Natl Acad. Sci. USA 110, 16474–16479 (2013).
Gunther, S. et al. Cell Stem Cell 13, 590–601 (2013).
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Goloviznina, N., Kyba, M. Twist of fate for skeletal muscle mesenchymal cells. Nat Cell Biol 19, 153–154 (2017). https://doi.org/10.1038/ncb3482
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DOI: https://doi.org/10.1038/ncb3482
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