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Growing, splitting and stacking myosin II filaments

Spectacular images of the process of myosin II filament formation and organization in migrating cells are unveiled by super-resolution imaging. A combination of short- and long-range interactions with actin filaments is seen to play a critical role in filament partitioning and alignment into contractile actin arcs and stress fibres.

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Figure 1: The cycle of non-muscle myosin II filament formation, partitioning and stacking.

References

  1. Burnette, D. T. et al. Nat. Cell Biol. 13, 371–381 (2011).

    Article  CAS  Google Scholar 

  2. Gordon, W. E. III Exp. Cell Res. 117, 253–260 (1978).

    Article  Google Scholar 

  3. Blanchoin, L., Boujemaa-Paterski, R., Sykes, C. & Plastino, J. Physiol. Rev. 94, 235–263 (2014).

    Article  CAS  Google Scholar 

  4. Vicente-Manzanares, M., Ma, X., Adelstein, R. S. & Horwitz, A. R. Nat. Rev. Mol. Cell. Biol. 10, 778–790 (2009).

    Article  CAS  Google Scholar 

  5. Verkhovsky, A. B., Svitkina, T. M. & Borisy, G. G. J. Cell Biol. 131, 989–1002 (1995).

    Article  CAS  Google Scholar 

  6. Beach, J. R. et al. Nat. Cell Biol. 19, 85–93 (2017).

    Article  CAS  Google Scholar 

  7. Hu, S. et al. Nat. Cell Biol. 19, 133–141 (2017).

    Article  CAS  Google Scholar 

  8. Fenix, A. M. et al. Mol. Biol. Cell 27, 1465–1478 (2016).

    Article  CAS  Google Scholar 

  9. Totsukawa, G. et al. J. Cell Biol. 150, 797–806 (2000).

    Article  CAS  Google Scholar 

  10. Rotty, J. D. et al. Dev. Cell 32, 54–67 (2015).

    Article  CAS  Google Scholar 

  11. Suarez, C. et al. Dev. Cell 32, 43–53 (2015).

    Article  CAS  Google Scholar 

  12. Tojkander, S. et al. Curr. Biol. 21, 539–550 (2011).

    Article  CAS  Google Scholar 

  13. Billington, N., Wang, A., Mao, J., Adelstein, R. S. & Sellers, J. R. J. Biol. Chem. 288, 33398–33410 (2013).

    Article  CAS  Google Scholar 

  14. Soares e Silva, M. et al. Proc. Natl Acad. Sci. USA 108, 9408–9413 (2011).

    Article  Google Scholar 

  15. Thoresen, T., Lenz, M. & Gardel, M. L. Biophys. J. 104, 655–665 (2013).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Margaret A. Titus.

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Titus, M. Growing, splitting and stacking myosin II filaments. Nat Cell Biol 19, 77–79 (2017). https://doi.org/10.1038/ncb3468

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