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CPEB4 links the clock and the UPR to protect the liver

Nature Cell Biology volume 19, pages 79–81 (2017)Cite this article

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Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

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Figure 1: Rhythmic transcription and UPR-mediated translation of Cpeb4 synchronize to protect hepatocytes against metabolic demand.

References

  1. Ma, Y. & Hendershot, L. M. Cell 107, 827–830 (2001).

    Article  CAS  Google Scholar 

  2. Oakes, S. A. & Papa, F. R. Annu. Rev. Pathol. 10, 173–194 (2015).

    Article  CAS  Google Scholar 

  3. Baiceanu, A., Mesdom, P., Lagouge, M. & Foufelle, F. Nat. Rev. Endocrinol. 12, 710–722 (2016).

    Article  CAS  Google Scholar 

  4. Rutkowski, D. T. et al. Dev. Cell 15, 829–840 (2008).

    Article  CAS  Google Scholar 

  5. Cretenet, G., Le Clech, M. & Gachon, F. Cell Metab. 11, 47–57 (2010).

    Article  CAS  Google Scholar 

  6. Pluquet, O. et al. Cancer Res. 73, 4732–4743 (2013).

    Article  CAS  Google Scholar 

  7. Koyanagi, S. et al. J. Biol. Chem. 286, 32416–32423 (2011).

    Article  CAS  Google Scholar 

  8. Maillo, C. et al. Nat. Cell Biol. 19, 94–105 (2017).

    Article  CAS  Google Scholar 

  9. Yoshino, J. & Klein, S. Diabetes 62, 2175–2177 (2013).

    Article  CAS  Google Scholar 

  10. Kojima, S., Sher-Chen, E. L. & Green, C. B. Genes Dev. 26, 2724–2736 (2012).

    Article  CAS  Google Scholar 

  11. Chakrabarti, A., Chen, A. W. & Varner, J. D. Biotechnol. Bioeng. 108, 2777–2793 (2011).

    Article  CAS  Google Scholar 

  12. Taniuchi, S., Miyake, M., Tsugawa, K., Oyadomari, M. & Oyadomari, S. Sci. Rep. 6, 32886 (2016).

    Article  CAS  Google Scholar 

  13. van der Spek, R., Kreier, F., Fliers, E. & Kalsbeek, A. Prog. Brain Res. 199, 183–201 (2012).

    Article  CAS  Google Scholar 

  14. Moreno, J. A. et al. Sci. Transl. Med. 5, 206ra138 (2013).

    Article  Google Scholar 

  15. Atkins, C. et al. Cancer Res. 73, 1993–2002 (2013).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Paul C. Moore and Scott A. Oakes are in the Department of Pathology, Diabetes Center, and Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, California 94143, USA,

    Paul C. Moore & Scott A. Oakes

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  1. Paul C. Moore
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  2. Scott A. Oakes
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Correspondence to Scott A. Oakes.

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Competing interests

S.A.O. is a founder, equity holder, and consultant for OptiKira, L.L.C. (Cleveland, Ohio).

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Moore, P., Oakes, S. CPEB4 links the clock and the UPR to protect the liver. Nat Cell Biol 19, 79–81 (2017). https://doi.org/10.1038/ncb3460

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