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Y chromothripsis?

Nature Cell Biology volume 19, pages 12–14 (2017)Cite this article

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Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.

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Figure 1: Model of chromothripsis after Y centromere inactivation and micronucleation.

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Authors and Affiliations

  1. Emily M. Hatch is in the Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, Washington 98109, USA,

    Emily M. Hatch

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  1. Emily M. Hatch
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Correspondence to Emily M. Hatch.

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The author declares no competing financial interests.

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Hatch, E. Y chromothripsis?. Nat Cell Biol 19, 12–14 (2017). https://doi.org/10.1038/ncb3458

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