Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO–LGR4/5–ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.
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Birchmeier, W. Orchestrating Wnt signalling for metabolic liver zonation. Nat Cell Biol 18, 463–465 (2016). https://doi.org/10.1038/ncb3349
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DOI: https://doi.org/10.1038/ncb3349
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