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Volume 18 Issue 12, December 2016

The coordinated movement of endothelial cells involves the engulfment of cadherin-rich protrusions by follower cells.p1311

Obituary

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News & Views

  • Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.

    • Lucia E. Rameh
    • Ashley M. Mackey
    News & Views
  • Many cell types in our body move in a collective manner, which requires individual cells to align their movements relative to that of their neighbours. A mechanism is now described in which cadherin-rich protrusions are extended from leading migrating cells and engulfed by follower cells to guide collective migration.

    • Tamal Das
    • Joachim P. Spatz
    News & Views
  • Work from the early 1980s reported strange lobes protruding from Caenorhabditis elegans germ cell precursors. However, the fate and potential significance of these lobes remained unexplored for decades. Now, neighbouring endodermal cells are shown to sever and digest these lobes, in an unexpected process of 'intercellular cannibalism', which could play an important part in regulating primordial germ cells.

    • Jennifer K. Heppert
    • Bob Goldstein
    News & Views
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