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Volume 18 Issue 1, January 2016

The centrosome promotes actin filament assembly through the activities of WASH and Arp2/3.

[article p65]

News & Views

  • The heptameric Arp2/3 complex generates branched actin filament networks that drive lamellipodium protrusion, vesicle trafficking and pathogen motility. Distinct variants of the Arp2/3 complex are now shown to have different roles in tuning actin assembly and disassembly, in concert with the prominent actin regulators cortactin and coronin.

    • Klemens Rottner
    • Theresia E. B. Stradal
    News & Views

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  • The heart is a complex organ, consisting of multiple cell types that coordinately regulate blood flow. Reciprocal Notch pathway signalling in endocardial and myocardial cells is now shown to promote maturation of the ventricular chambers. These insights reveal mechanisms that, when disrupted, can lead to cardiomyopathies.

    • Casey A. Gifford
    • Deepak Srivastava
    News & Views
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