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Actin shapes the autophagosome

Nature Cell Biology volume 17, pages 1094–1096 (2015)Cite this article

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Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.

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Figure 1: Actin shapes autophagosome structures from inside the isolation membrane.

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Authors and Affiliations

  1. Petter Holland and Anne Simonsen are in the Department of Molecular Medicine, Insititute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway,

    Petter Holland & Anne Simonsen

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  1. Petter Holland
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  2. Anne Simonsen
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Correspondence to Anne Simonsen.

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Holland, P., Simonsen, A. Actin shapes the autophagosome. Nat Cell Biol 17, 1094–1096 (2015). https://doi.org/10.1038/ncb3224

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