A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and disentanglement of sister chromatids and by conferring rigidity to chromosomes.
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Nagasaka, K., Hirota, T. Clarifying the role of condensin in shaping chromosomes. Nat Cell Biol 17, 711–713 (2015). https://doi.org/10.1038/ncb3183
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DOI: https://doi.org/10.1038/ncb3183
