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A niche role for periostin and macrophages in glioblastoma

Nature Cell Biology volume 17, pages 107–109 (2015)Cite this article

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Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances glioblastoma progression in mice.

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Figure 1: GSCs recruit and activate TAMs by secreting POSTN.
Figure 2: Effects of TAM depletion or reprogramming on experimental glioblastomas in mice.

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Authors and Affiliations

  1. Mario Leonardo Squadrito and Michele De Palma are at the Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland,

    Mario Leonardo Squadrito & Michele De Palma

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  1. Mario Leonardo Squadrito
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  2. Michele De Palma
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Correspondence to Michele De Palma.

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Squadrito, M., De Palma, M. A niche role for periostin and macrophages in glioblastoma. Nat Cell Biol 17, 107–109 (2015). https://doi.org/10.1038/ncb3095

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