Despite the widespread occurrence of aneuploidy in cancer cells, the molecular causes for chromosomal instability are not well established. Cyclin B2 is now shown to control a pathway — involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 — the alteration of which causes defective centrosome separation, aneuploidy and tumour development.
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de Cárcer, G., Malumbres, M. A centrosomal route for cancer genome instability. Nat Cell Biol 16, 504–506 (2014). https://doi.org/10.1038/ncb2978
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DOI: https://doi.org/10.1038/ncb2978
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