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Galectins CLIC cargo inside

Nature Cell Biology volume 16, pages 506–507 (2014)Cite this article

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Clathrin-independent endocytosis removes membrane receptors and other proteins from the cell surface, yet the mechanisms controlling this process remain unclear. Galectin-3 is now shown to regulate the biogenesis of a subpopulation of clathrin-independent carriers (CLICs). Galectin-3 binds to glycosylated cargo proteins and interacts with membrane glycosphingolipids to induce membrane deformation and CLIC formation.

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Figure 1: A model for CLIC endocytosis driven by galectin-3 (Gal3).

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  1. Pamela Stanley is in the Department of Cell Biology, Albert Einstein College of Medicine, New York, 10461, USA,

    Pamela Stanley

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  1. Pamela Stanley
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Correspondence to Pamela Stanley.

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Stanley, P. Galectins CLIC cargo inside. Nat Cell Biol 16, 506–507 (2014). https://doi.org/10.1038/ncb2983

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