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Cadherin adhesion controlled by cortical actin dynamics

Nature Cell Biology volume 16, pages 508–510 (2014)Cite this article

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Cadherin-containing cell–cell junctions respond to intercellular tension by increasing their size, strength and complexity. The mechanical regulation of cadherin adhesions is now shown to involve myosin-dependent tension in the cortical actomyosin cytoskeleton. This reduces actin turnover to decrease the mobility of cadherin molecules and increase their concentration at junctions.

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Figure 1: Cortical actomyosin tension regulates cadherin adhesions.

References

  1. Aguilar-Cuenca, R., Juanes-Garcia, A. & Vicente-Manzanares, M. Cell. Mol. Life Sci. 71, 479–492 (2014).

    Article  CAS  Google Scholar 

  2. Rauzi, M., Lenne, P. F. & Lecuit, T. Nature 468, 1110–1114 (2010).

    Article  CAS  Google Scholar 

  3. Maitre, J. L. et al. Science 338, 253–256 (2012).

    Article  CAS  Google Scholar 

  4. Discher, D. E., Janmey, P. & Wang, Y. L. Science 310, 1139–1143 (2005).

    Article  CAS  Google Scholar 

  5. Lu, P., Weaver, V. M. & Werb, Z. J. Cell Biol. 196, 395–406 (2012).

    Article  CAS  Google Scholar 

  6. Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A. & Shibata, M. Nat. Cell Biol. 12, 533–542 (2010).

    Article  CAS  Google Scholar 

  7. Twiss, F. & de Rooij, J. Cell. Mol. Life Sci. 70, 4101–4116 (2013).

    Article  CAS  Google Scholar 

  8. De Rooij, J., Kerstens, A., Danuser, G., Schwartz, M. A. & Waterman-Storer, C. M. J. Cell Biol. 171, 153–164 (2005).

    Article  CAS  Google Scholar 

  9. Engl, W., Arasi, B., Yap, L. L., Thiery, J. P. & Viasnoff, V. Nat. Cell Biol. 16, 584–591 (2014).

    Article  Google Scholar 

  10. Hong, S., Troyanovsky, R. B. & Troyanovsky, S. M. J. Cell Biol. 201, 131–143 (2013).

    Article  CAS  Google Scholar 

  11. Truong Quang, B. A., Mani, M., Markova, O., Lecuit, T. & Lenne, P. F. Curr. Biol. 23, 2197–2207 (2013).

    Article  CAS  Google Scholar 

  12. Wu, S. K. et al. Nat. Cell Biol. 16, 167–178 (2014).

    Article  CAS  Google Scholar 

  13. Huveneers, S. et al. J. Cell Biol. 196, 641–652 (2012).

    Article  CAS  Google Scholar 

  14. Liu, Z. et al. Proc. Natl. Acad. Sci. USA 107, 9944–9949 (2010).

    Article  CAS  Google Scholar 

  15. Pannekoek, W. J., Post, A. & Bos, J. L. Cell Adhes. Migrat. http://dx.doi.org/10.4161/cam.27352 (2014).

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  1. Johan de Rooij is in Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands,

    Johan de Rooij

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  1. Johan de Rooij
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Correspondence to Johan de Rooij.

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de Rooij, J. Cadherin adhesion controlled by cortical actin dynamics. Nat Cell Biol 16, 508–510 (2014). https://doi.org/10.1038/ncb2980

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