Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.
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Joshi, S., Ryan, K. Autophagy chews Fap to promote apoptosis. Nat Cell Biol 16, 23–25 (2014). https://doi.org/10.1038/ncb2899
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DOI: https://doi.org/10.1038/ncb2899
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