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Autophagy chews Fap to promote apoptosis

Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.

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Figure 1: Multiple roles of autophagy in cell survival and death.
Figure 2: Autophagic degradation of Fap-1 promotes Fas-induced apoptosis.

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Correspondence to Kevin M. Ryan.

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Joshi, S., Ryan, K. Autophagy chews Fap to promote apoptosis. Nat Cell Biol 16, 23–25 (2014). https://doi.org/10.1038/ncb2899

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