Abstract
Epithelial cells have an apical–basolateral axis of polarity, which is required for epithelial functions including barrier formation, vectorial ion transport and sensory perception. Here we review what is known about the sorting signals, machineries and pathways that maintain this asymmetry, and how polarity proteins interface with membrane-trafficking pathways to generate membrane domains de novo. It is becoming apparent that membrane traffic does not simply reinforce polarity, but is critical for the generation of cortical epithelial cell asymmetry.
Epithelial cells have an apical–basolateral axis of polarity, which is required for epithelial functions including barrier formation, vectorial ion transport and sensory perception. Here we review what is known about the sorting signals, machineries and pathways that maintain this asymmetry, and how polarity proteins interface with membrane-trafficking pathways to generate membrane domains de novo.It is becoming apparent that membrane traffic does not simply reinforce polarity, but is critical for the generation of cortical epithelial cell asymmetry.
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Acknowledgements
This work was supported by National Institutes of Health grants R37DK54425 and RO1DK077777 (to G.A.) and K99CA163535 (to D.M.B.).
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Apodaca, G., Gallo, L. & Bryant, D. Role of membrane traffic in the generation of epithelial cell asymmetry. Nat Cell Biol 14, 1235–1243 (2012). https://doi.org/10.1038/ncb2635
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DOI: https://doi.org/10.1038/ncb2635
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