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The transcriptional and signalling networks of pluripotency

Nature Cell Biology volume 13, pages 490–496 (2011)Cite this article

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Abstract

Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is maintained by a network of transcription factors and is influenced by specific signalling pathways. Current evidence indicates that multiple pluripotent states can exist in vitro. Here we review the recent advances in studying the transcriptional regulatory networks that define pluripotency, and elaborate on how manipulation of signalling pathways can modulate pluripotent states to varying degrees.

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Figure 1: Crosstalk between transcriptional regulatory networks, epigenetic and non-coding RNA networks.
Figure 2: Interconversion of pluripotent states for mouse and human cells.

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Acknowledgements

We thank A. Hutchins, D. Heng and J-H. Ng for critical comments on the manuscript.

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Authors and Affiliations

  1. Singapore; the Department of Biochemistry, Singapore; the Department of Biological Sciences, Huck-Hui Ng is at the Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672, National University of Singapore, Singapore 117597, National University of Singapore, Singapore 117597, Singapore and the School of Biological Sciences, Nanyang Technological University, Singapore 639798, Singapore,

    Huck-Hui Ng

  2. the Department of Biochemistry, National University of Singapore, Singapore 117597, Singapore,

    Huck-Hui Ng

  3. Azim Surani is at the Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK,

    M. Azim Surani

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Correspondence to Huck-Hui Ng or M. Azim Surani.

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Ng, HH., Surani, M. The transcriptional and signalling networks of pluripotency. Nat Cell Biol 13, 490–496 (2011). https://doi.org/10.1038/ncb0511-490

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