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Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution

Nature Cell Biology volume 13, pages 197–199 (2011)Cite this article

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In response to major cellular insults, a massive increase in lysosomal membrane permeability (LMP) leads to necrosis. Data now reveal that this potent lysosomal-mediated necrotic cell-death machinery can also be harnessed for complex physiological processes, such as post-lactation mammary gland involution.

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Figure 1: Lysosomal-mediated necrotic cell death during mammary gland involution.

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  1. Cliff J. Luke and Gary A. Silverman are in the Departments of Pediatrics and Cell Biology & Physiology, The University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA. gsilverman@upmc.edu,

    Cliff J. Luke & Gary A. Silverman

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  1. Cliff J. Luke
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  2. Gary A. Silverman
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The authors declare no competing financial interests.

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Luke, C., Silverman, G. Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution. Nat Cell Biol 13, 197–199 (2011). https://doi.org/10.1038/ncb0311-197

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