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A new chisel for sculpting Darwin's endless forms

Nature Cell Biology volume 12, pages 528–529 (2010)Cite this article

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The distribution of secreted morphogens in a developing organ determines its form by instructing size, shape and pattern. Pentagone has been identified as a secreted factor that controls the distribution of the morphogen Decapentaplegic (Dpp) in the Drosophila melanogaster wing.

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Figure 1: Pentagone and Dally facilitate morphogen mobility.

References

  1. Day, S. J. & Lawrence, P. A. Development 127, 2977–2987 (2000).

    CAS  PubMed  Google Scholar 

  2. Tabata, T. & Takei, Y. Development 131, 703–712 (2004).

    Article  CAS  Google Scholar 

  3. Rogulja, D. & Irvine, K. D. Cell 123, 449–461 (2005).

    Article  CAS  Google Scholar 

  4. Adachi-Yamada, T., Fujimura-Kamada, K., Nishida, Y. & Matsumoto, K. Nature 400, 166–169 (1999).

    Article  CAS  Google Scholar 

  5. Crickmore, M. A. & Mann, R. S. Science 313, 63–68 (2006).

    Article  CAS  Google Scholar 

  6. Darwin, C. R. On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life (John Murray, 1859).

    Book  Google Scholar 

  7. Lin, X. Development 131, 6009–6021 (2004).

    Article  CAS  Google Scholar 

  8. Fujise, M. et al. Development 130, 1515–1522 (2003).

    Article  CAS  Google Scholar 

  9. Crickmore, M. A. & Mann, R. S. Development 134, 327–334 (2007).

    Article  CAS  Google Scholar 

  10. Belenkaya, T. Y. et al. Cell 119, 231–244 (2004).

    Article  CAS  Google Scholar 

  11. Vuilleumier, R. et al. Nat. Cell Biol. 12, 611–617 (2010).

    Article  CAS  Google Scholar 

  12. Pyrowolakis, G., Hartmann, B., Muller, B., Basler, K. & Affolter, M. Dev. Cell 7, 229–240 (2004).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Richard S. Mann is in the Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York USA. rsm10@columbia.edu; mcrickmore@rockefeller.edu

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  1. Michael Crickmore is in the Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York USA.,

    Michael Crickmore & Richard S. Mann

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  1. Michael Crickmore
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  2. Richard S. Mann
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Crickmore, M., Mann, R. A new chisel for sculpting Darwin's endless forms. Nat Cell Biol 12, 528–529 (2010). https://doi.org/10.1038/ncb0610-528

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