Transcriptional noise has an important role in generating diversity in cellular populations that are seemingly identical. As this noise stems from the inherent stochasticity of gene expression, it has been unclear whether it is directly controlled. Dig1, a regulator of the budding yeast mating pathway, is now shown to prevent transcriptional noise by regulating the spatial organization of downstream gene targets.
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References
Spudich, J. L. & Koshland, D. J. Nature 262, 467–471 (1976).
Swain, P. S., Elowitz, M. B. & Siggia, E. D. Proc. Natl Acad. Sci. USA 99, 12795–12800 (2002).
Elowitz, M. B., Levine, A. J., Siggia, E. D. & Swain, P. S. Science 297, 1183–1186 (2002).
Raser, J. M. & O'Shea, E. K. Science 304, 1811–1814 (2004).
Colman-Lerner, A. et al. Nature 437, 699–706 (2005).
Yu, R. C. et al. Nature 456, 755–761 (2008).
McCullagh, E., Seshan, A., El-Samad, H. & Madhani, H. D. Nat. Cell Biol. 12, 954–962 (2010).
Osborne, C. S. et al. Nat. Genet. 36, 1065–1071 (2004).
Spilianakis, C. G., Lalioti, M. D., Town, T., Lee, G. R. & Flavell, R. A. Nature 435, 637–645 (2005).
Schoenfelder, S. et al. Nat. Genet. 42, 53–61 (2010).
Kosak, S. T. & Groudine, M. Science 306, 644–647 (2004).
Rajapakse, I. et al. Proc. Natl Acad. Sci. USA 106, 6679–6684 (2009).
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Neems, D., Kosak, S. Turning down the volume on transcriptional noise. Nat Cell Biol 12, 929–931 (2010). https://doi.org/10.1038/ncb1010-929
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DOI: https://doi.org/10.1038/ncb1010-929
