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Axon growth-stimulus package includes local translation

Nature Cell Biology volume 11, pages 919–921 (2009)Cite this article

Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.

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Figure 1: Localized polarity protein translation in axons and epithelial cells.

References

  1. Hengst, U. et al. Nature Cell Biol. 11 1024–1030 (2009).

    Article  CAS  Google Scholar 

  2. Taylor, A. M. et al. Nature Methods 2, 599–605 (2005).

    Article  CAS  Google Scholar 

  3. Hengst, U., Cox, L. J., Macosko, E. Z. & Jaffrey, S. R. J. Neurosci. 26, 5727–5732 (2006).

    Article  CAS  Google Scholar 

  4. Goldstein, B. & Macara, I. G. Dev. Cell 13, 609–622 (2007).

    Article  CAS  Google Scholar 

  5. Knoblich, J. A. Cell 132, 583–597 (2008).

    Article  CAS  Google Scholar 

  6. Aranda, V. et al. Nature Cell Biol. 8, 1235–1245 (2006).

    Article  CAS  Google Scholar 

  7. Kim, M. et al. J. Cell Sci. 120, 2309–2317 (2007).

    Article  CAS  Google Scholar 

  8. Joberty, G., Petersen, C., Gao, L. & Macara, I. G. Nature Cell Biol. 2, 531–539 (2000).

    Article  CAS  Google Scholar 

  9. Czaplinski, K. & Singer, R. H. Trends Biochem. Sci. 31, 687–693 (2006).

    Article  CAS  Google Scholar 

  10. Martin, K. C. & Ephrussi, A. Cell 136, 719–730 (2009).

    Article  CAS  Google Scholar 

  11. Wang, D. O. et al. Science 324, 1536–1540 (2009).

    Article  CAS  Google Scholar 

  12. Massarwa, R., Schejter, E. D. & Shilo, B. Z. Dev. Cell 16, 877–888 (2009).

    Article  CAS  Google Scholar 

  13. Horne-Badovinac, S. & Bilder, D. PLoS Genet. 4, e8 (2008).

    Article  Google Scholar 

  14. Li, Z., Wang, L., Hays, T. S. & Cai, Y. J. Cell Biol. 180, 31–38 (2008).

    Article  CAS  Google Scholar 

  15. Lalli, G. J. Cell Sci. 122, 1499–1506 (2009).

    Article  CAS  Google Scholar 

  16. Etienne-Manneville, S. & Hall, A. Nature 421, 753–756 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Ian G. Macara, Hidekazu Iioka and Stavroula Mili are in the Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908-0577, USA. igm9c@virginia.edu,

    Ian G. Macara, Hidekazu Iioka & Stavroula Mili

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  1. Ian G. Macara
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  2. Hidekazu Iioka
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  3. Stavroula Mili
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Macara, I., Iioka, H. & Mili, S. Axon growth-stimulus package includes local translation. Nat Cell Biol 11, 919–921 (2009). https://doi.org/10.1038/ncb0809-919

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