News and Views

Nature Cell Biology 11, 921 - 923 (2009)
doi:10.1038/ncb0809-921

SASPense and DDRama in cancer and ageing

Marzia Fumagalli1 & Fabrizio d'Adda di Fagagna1

  1. Marzia Fumagalli and Fabrizio d'Adda di Fagagna are at the IFOM Foundation - FIRC Institute of Molecular Oncology Foundation, via Adamello 16, 20139 Milan, Italy.
    e-mail: fabrizio.dadda@ifom-ieo-campus.it

Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.

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