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Nature Cell Biology 11, 787–789 (1 July 2009) | doi:10.1038/ncb1902
Chromosome congression: on the bi-orient express
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Abstract
Accurate chromosome segregation requires that chromosomes bi-orient, or attach to microtubules emanating from opposite ends of a bipolar spindle, such that at anaphase, when the molecular glue holding chromosome pairs together (cohesion) is dissolved, chromosomes are flawlessly segregated into each daughter cell. Chromosomes attach to the spindle through kinetochores, proteinaceous structures that assemble on centromeric DNA.
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