1. Emily A. Foley and Tarun M. Kapoor are at Rockefeller University, 1230 York Avenue, NY 10065, USA.
   e-mail: kapoor@mail.rockefeller.edu

Abstract

Errors in chromosome–spindle attachments during cell division can lead to an irreversible change in chromosome number. Proper connections between chromosomes and spindle microtubules can be promoted by both chromosome-intrinsic and extrinsic mechanisms during mitosis and meiosis.

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