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Letter
Nature Cell Biology 11, 739–746 (1 June 2009) | doi:10.1038/ncb1880
The Patched dependence receptor triggers apoptosis through a DRAL|[ndash]|caspase-9 complex
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Abstract
Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis. Besides its classic morphogenic activity, Shh is also a survival factor.
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