1. Ralph A. Neumüller and Juergen A. Knoblich are at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Dr. Bohr Gasse 3, 1030 Vienna, Austria.
   e-mail: Juergen.Knoblich@imba.oeaw.ac.at

Abstract

Stem cells achieve the remarkable task of generating both identical copies of themselves and lineage-restricted daughter cells that ultimately undergo terminal differentiation. The differential regulation of ribosomal protein biosynthesis helps to generate these two outcomes in Drosophila melanogaster.

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