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Letter
Nature Cell Biology 11, 624–630 (1 May 2009) | doi:10.1038/ncb1868
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration
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Abstract
Cell migration is a dynamic process that requires temporal and spatial regulation of integrin activation and focal adhesion assembly/disassembly. Talin, an actin and β-integrin tail-binding protein, is essential for integrin activation and focal adhesion formation.
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