News and Views
Nature Cell Biology 11, 540 - 542 (2009)
doi:10.1038/ncb0509-540
SCAI blocks MAL-evolent effects on cancer cell invasion
Rudy Juliano1
-
Rudy Juliano is in the Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599-7365, USA.
e-mail: arjay@med.unc.edu
Abstract
SCAI is a newly discovered protein that reduces cancer cell invasiveness. SCAI inhibits the MAL/SRF transcriptional activator complex that is downstream of Rho GTPase and actin, resulting in reduced expression of 
1-integrins and loss of invasive potential.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β 1 -integrinNature Cell Biology Article (01 May 2009)
Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MALThe EMBO Journal Article (03 Dec 2008)
Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MALThe EMBO Journal Article (13 Oct 2004)
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expressionNature Letters to Editor (11 Mar 2004)
See all 10 matches for Research
