News and Views
Nature Cell Biology 11, 538 - 540 (2009)
doi:10.1038/ncb0509-538
Smurf1 zaps the talin head
David R. Critchley1
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David Critchley is in the Department of Biochemistry, University of Leicester, Leicester LE17RH, UK.
e-mail: drc@le.ac.uk
Abstract
Focal adhesion turnover is essential for cell migration. New results show that the talin head liberated from talin by calpain II cleavage has a key role in these events, and that its levels are tightly regulated by Smurf1-mediated ubiquitylation counteracted by Cdk5-mediated phosphorylation.
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