1. Dorothea Godt and Ulrich Tepass are in the Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada.
   e-mail: d.godt@utoronto.ca; e-mail: u.tepass@utoronto.ca

Abstract

Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.

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