Review abstract
Nature Cell Biology 11, 527 - 534 (2009)
doi:10.1038/ncb0509-527
Viral avoidance and exploitation of the ubiquitin system
Felix Randow1 & Paul J. Lehner2
Abstract
The versatility of ubiquitin in regulating protein function and cell behaviour through post-translational protein modification makes it a particularly attractive target for viruses. Here we review how viruses manipulate the ubiquitin system to favour their propagation by redirecting cellular ubiquitin enzymes or encoding their own ubiquitin components to enable replication, egress and immune evasion. These studies not only reveal the many cellular processes requiring ubiquitin but also illustrate how viruses usurp their host cells.
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Felix Randow is in the Division of Protein and Nucleic Acid Chemistry, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
e-mail: randow@mrc-lmb.cam.ac.uk -
Paul J. Lehner is in the Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 0XY, UK.
e-mail: pjl30@cam.ac.uk
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