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Volume 11 Issue 4, April 2009

p53-cofactor JMY nucleates actin filaments in cells. Expression of the actin nucleation region of JMY in U2OS cells induces the formation of actin filaments (phalloidin, red).letter p451

Editorial

  • Is the UK still committed to basic biology research?

    Editorial

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  • A series of essays describing pivotal events in the careers of cell biologists.

    Editorial
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Turning Points

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Review Article

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News & Views

  • The assembly of actin networks is dependent on nucleation-promoting factors. A new study identifies JMY as a protein containing two separate nucleation-promoting activities that shuttles between the nucleus and the cytoplasm and promotes cell migration. These observations indicate that JMY is an important factor controlling actin dynamics in motile cells.

    • David W. Roadcap
    • James E. Bear
    News & Views
  • To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt — a major kinase that coordinates diverse signalling pathways — phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.

    • Karin Ecker
    • Ludger Hengst
    News & Views
  • Ubiquitin E3 ligases of the RING and HECT families are distinct not only in their catalytic mechanisms but also in targeting substrates. Now it seems that one heterodimeric complex can target substrates to both types of E3 ligase.

    • Sarah Jackson
    • Yue Xiong
    News & Views
  • Depletion of Ca2+ from intracellular stores has long been known to signal to and activate plasma membrane 'store-operated' channels. We now learn that store depletion also controls the formation of cyclic AMP (cAMP) through the regulation of adenylyl cyclase (A-Cyclase). These findings substantially broaden the scope and biological significance of Ca2+ store-regulated signalling.

    • James W. Putney Jr
    News & Views
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Research Highlights

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Article

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Letter

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Erratum

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