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Nature Cell Biology 11, 379 - 381 (2009)
doi:10.1038/ncb0409-379
Targeting protein ubiquitylation: DDB1 takes its RING off
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Sarah Jackson and Yue Xiong are in the Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA.
e-mail: yxiong@email.unc.edu
Abstract
Ubiquitin E3 ligases of the RING and HECT families are distinct not only in their catalytic mechanisms but also in targeting substrates. Now it seems that one heterodimeric complex can target substrates to both types of E3 ligase.
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