News and Views
Nature Cell Biology 11, 377 - 379 (2009)
doi:10.1038/ncb0409-377
Skp2: caught in the Akt
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Karin Ecker and Ludger Hengst are in the Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck Austria.
e-mail: ludger.hengst@i-med.ac.
Abstract
To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt — a major kinase that coordinates diverse signalling pathways — phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.
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