News and Views
Nature Cell Biology 11, 118 - 120 (2009)
doi:10.1038/ncb0209-118
Casting back to stem cells
Shosei Yoshida1
-
Shosei Yoshida is in the Division of Germ Cell Biology, National Institute for Basic Biology, 444-8989, Okazaki, Japan.
e-mail: shosei@nibb.ac.jp
Abstract
In the classical view, adult stem cells and their differentiating progeny are considered to be distinct entities in an irreversible sequence of development. However, emerging evidence suggests that this distinction may not be so definitive. Recent work in the mouse shows that a population of differentiating spermatogonia, when transplanted, can 'de-differentiate' into functional self-renewing stem cells.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Mouse differentiating spermatogonia can generate germinal stem cells in vivoNature Cell Biology Letter (01 Feb 2009)
A luminal epithelial stem cell that is a cell of origin for prostate cancerNature Article (24 Sep 2009)
Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumorsNature Genetics Letter (01 Nov 2009)
