News and Views
Nature Cell Biology 11, 116 - 118 (2009)
doi:10.1038/ncb0209-116
Linear polyubiquitylation: the missing link in NF–
B signalling
Arthur L. Haas1
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Arthur L. Haas is in the Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine, 1901 Perdido Street, New Orleans, LA 70112, USA.
e-mail: ahaas@lsuhsc.edu
Abstract
Metazoan cells respond to external stress or infection through multiple signalling pathways that converge on NF–
B activation, initiating a program designed to promote survival or trigger cell death. Recent evidence reveals a mechanism for NF-B activation that requires assembly of linear polyubiquitin chains as scaffolds to recruit the activation complex.
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