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Nature Cell Biology 11, 114 - 116 (2009)
doi:10.1038/ncb0209-114
Alzheimer's dementia by circulation disorders: when trees hide the forest
Carlos G. Dotti1 & Bart De Strooper1
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Carlos G. Dotti and Bart De Strooper are in the VIB Department of Molecular and Developmental Genetics (VIB11) and Center for Human Genetics, Katholieke Universiteit Herestraat 49, PO Box 603 3000, Leuven, Leuven, Belgium.
e-mail: Carlos.Dotti@med.kuleuven.be
Abstract
Deposition of amyloid 
-peptide in cerebral vessel walls, termed cerebral amyloid angiopathy (CAA), enhances the cognitive deficits associated with Alzheimer's disease. The molecular details by which circulatory defects with hypoxia alter peptide clearance, contributing to brain deposition and AD, are beginning to be elucidated.
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