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Letter
Nature Cell Biology 11, 1363–1369 (1 November 2009) | doi:10.1038/ncb1983
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
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Abstract
The anaphase-promoting complex (APC/C), a ubiquitin ligase, is the target of the spindle-assembly checkpoint (SAC), and it ubiquitylates protein substrates whose degradation regulates progress through mitosis. The identity of the ubiquitin-conjugating (E2) enzymes that work with the APC/C is unclear.
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