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Letter
Nature Cell Biology 11, 1355–1362 (1 November 2009) | doi:10.1038/ncb1980
FLIP-mediated autophagy regulation in cell death control
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Abstract
Autophagy is an active homeostatic degradation process for the removal or turnover of cytoplasmic components wherein the LC3 ubiquitin-like protein undergoes an Atg7 E1-like enzyme/Atg3 E2-like enzyme-mediated conjugation process to induce autophagosome biogenesis. Besides its cytoprotecive role, autophagy acts on cell death when it is abnormally upregulated.
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