1. Lauren Matise, Michael Pickup and Harold Moses are at the Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232-6838, USA. e-mail: hal.moses@vanderbilt.edu.

Abstract

Intravital imaging demonstrates that TGF- signalling regulates the mode of cancer cell motility. Cells with active TGF- signalling migrate as single cells and are capable of hematogenous and lymphatic spread, whereas cells lacking TGF- signalling invade lymphatics collectively.

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