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Nature Cell Biology 11, 1177 - 1179 (2009)
doi:10.1038/ncb1009-1177
A motor driving PTEN
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Jing Zhou and Luis F. Parada are in the Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
e-mail: jing.zhou@utsouthwestern.edu; e-mail: luis.parada@utsouthwestern.edu
Abstract
To fulfil its lipid phosphatase function, PTEN must be in close proximity to the plasma membrane where its substrates reside. PTEN translocation to the plasma membrane is an active process that is mediated by the myosin-based transport machinery. MyosinV controls PTEN membrane association and thus, PTEN-mediated cell growth in neurons.
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RESEARCH
MyosinV controls PTEN function and neuronal cell sizeNature Cell Biology Letter (01 Oct 2009)
