1. Eran Meshorer and Yosef Gruenbaum are in the Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra campus, Jerusalem 91904, Israel.
   e-mail: meshorer@cc.huji.ac.il; e-mail: gru@vms.huji.ac.il

Abstract

Progerin, a mutated form of lamin A, causes the premature ageing disease Hutchinson-Gilford progeria syndrome and is also involved in normal ageing. Progerin accumulation leads to distinct chromatin-related defects and the NURD complex appears to affect ageing-related chromatin defects.

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