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Nature Cell Biology 11, 1174 - 1175 (2009)
doi:10.1038/ncb1009-1174
A bacterial virulence factor that dissipates tension
Stéphane Romero1 & Guy Tran Van Nhieu1
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Stéphane Romero and Guy Tran Van Nhieu are in the department of Biology, College de France, Inserm U971, Paris, France.
e-mail: guy.tran-van-nhieu@college-de-france.fr
Abstract
Various microbes harness the actin polymerization machinery through their surface proteins to allow intracellular motility within host cells, but other virulence factors regulate dissemination. The cortical actin tension of polarized cells may represent a physical barrier that hinders the formation of microbial protrusions during cell-to-cell spreading.
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