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Nature Cell Biology 11, 13 (2009)
doi:10.1038/ncb0109-13
sFRPs: a declaration of (Wnt) independence
Elisha Nathan1 & Eldad Tzahor1
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Elisha Nathan and Eldad Tzahor are in the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.
e-mail: eldad.tzahor@weizmann.ac.il
Abstract
Secreted Frizzled-related proteins (sFRPs) are signalling molecules well-known as antagonists of the Wnt pathway, but recent studies indicate that they may have additional functions unrelated to Wnt. A new study demonstrates that mammalian sFRP2 can act as an enhancer of collagen processing in vitro and in vivo, augmenting myocardial injury-driven fibrosis. These findings underscore the biological versatility of sFRP family members.
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