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Letter
Nature Cell Biology 10, 1098–1105 (1 September 2008) | doi:10.1038/ncb1770
p53 mRNA controls p53 activity by managing Mdm2 functions
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Abstract
The E3 ubiquitin ligase Mdm2 is a focal regulator of p53 tumour suppressor activity. It binds p53, promoting its polyubiquitination and degradation, and also controls p53 synthesis.
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