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Letter

Nature Cell Biology 10, 1114–1122 (1 September 2008) | doi:10.1038/ncb1772

Epigenetic transcriptional repression of cellular genes by a viral SET protein

Shiraz Mujtaba , Karishma L. Manzur , James R. Gurnon , Ming Kang , James L. Van Etten & Ming-Ming Zhou

Viruses recruit host proteins to secure viral genome maintenance and replication. However, whether they modify host histones directly to interfere with chromatin-based transcription is unknown.